Webinars

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for the upcoming Building Worlds webinars please see here 

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Rommie Amaro

University of California San Diego, USA

Wednesday, 15th of April 5pm (UK)

Computational Microscopy of COVID-19

I will discuss our lab’s efforts, together with collaborators, to understand the SARS-CoV-2 virus in atomic detail, with the goals to better understand molecular recognition of the virus and host cell receptors, antibody binding and design, and the search for novel therapeutics.

Hosted by the School of Chemistry

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Douglas Pike

Rutgers University, USA

Wednesday, 22nd of April 4pm (UK)

From Structure to Function of Primordial Enzymes

Life on Earth is driven by electron transfer reactions, catalyzed by a suite of essential enzymes. Most modern enzymes are complex in their structure and chemistry and must have evolved from a smaller set of ancestral protein folds. Ancient oxidoreductase enzymes, from the Archean Eon between ca. 3.5 and 2.5 billion years ago, have been long extinct, making it challenging to retrace evolution by sequence-based phylogeny or ancestral sequence reconstruction. However, three-dimensional topologies of proteins change more slowly than sequences, and by using comparative structural analysis, we can quantify the similarity between enzyme active sites that are conserved across the tree of life. As structural landmarks, these conserved fold motifs can be employed as scaffolds for in silico ‘evolution’ to design enzymes that are simple, functional and could have occurred spontaneously on the early Earth.

Hosted by the School of Chemistry 
UoE_Centred Logo_CMYK_v1_160215
Part of the Building Worlds Seminar Series
building_TRANSP-01
 by the UK Centre of Astrobiology
Screenshot 2020-02-05 at 16.56.57

Khalil Hanna

Ecole Nationale Supérieure de Chimie de Rennes, France

Friday, 24th of April 2pm (UK)

Sorption and redox reactions at mineral/water interfaces

Fe-oxyhydroxides are generally the dominant redox-active components in soils, sediments, and other oxide-rich environments. These metal oxides can vary widely in physical and chemical characteristics, and exist as micro- and nano-sized particles. From an engineering point of view, Fe-mediated redox reactions can be potentially applicable for environmental remediation and protection. From an environmental point of view, they can affect a wide range of processes, including biogeochemical cycling and availability of trace elements, degradation of organic matter and transport and mobility of emerging contaminants.

My research group in Rennes is engaged in elucidating molecular-scale reactions at mineral surfaces, and in translating molecular-level information to observations made at the larger scales using thermodynamics and reactive transport modelling. Our research interests focus on combining experimental investigations and modelling at different scales in order to improve understanding of sorption and heterogeneous redox reactions taking place at oxide/water interfaces.

Overall, this talk gives some examples of our recent works on the implications of Fe-oxyhydroxides in sorption and redox reactions and reactive transport of pharmaceutical compounds.

Hosted by the School of Chemistry
UoE_Centred Logo_CMYK_v1_160215

 


Steve Ruff

Mars Space Flight Facility, Arizona State University, USA

Wednesday, 24th of June 5pm (UK)

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Lessons from Hot Springs on Earth Applied to the Search for Traces of Life on Mars

Ancient hot spring deposits have long been recognized as key exploration targets in the search for past life on Mars because they are known on Earth to harbor microbial life and preserve traces of it in the rock record.  They also are recognized as a possible cradle of life on Earth, adding to the importance of finding hot spring settings on Mars.  In 2007, the Mars Exploration Rover Spirit encountered outcrops and soil composed of nearly pure opaline silica (amorphous SiO2Ÿ*nH2O) in the Columbia Hills of Gusev crater.  Such materials commonly form around hot springs, but geochemical observations were used in this case to discount this possibility.  Years later, following the recognition that a suite of features from terrestrial hot spring settings is evident at the Spirit site, the case for hot spring deposits there is robust.  Among the features are possible traces of life preserved in the opaline silica rocks, which was not recognized during the operational lifetime of the rover. Consequently, this provocative scenario remains untested.

Part of the Building Worlds Seminar Series
building_TRANSP-01
 by the UK Centre of Astrobiology
Screenshot 2020-02-05 at 16.56.57

Dr Nicola Mari

Mars: A Still Volcanically Active World?

Wednesday 7th October, 3.30pm

Today it is still unknown whether Mars has volcanic activity or, in general, if the Martian interior is geologically active. Martian meteorites are, at the moment, the only geological samples from Mars that are available to answer these questions at the geochemical level. Most of them are volcanic rocks, and the most abundant types are the shergottites (basalts), nakhlites (clinopyroxenites), and chassignites (olivine cumulates). Mars is characterised by a stagnant-lid geodynamic regime, without evidence of homogenization of the mantle after the end of the last magma ocean phase (~4.5 billion years ago). These samples therefore carry invaluable information about the interior of Mars.

The Tissint Martian meteorite was investigated in this work, since it is the meteorite that is most representative of the Martian mantle. This meteorite was analysed with the objective of obtaining information about the thermal state and convective activity in the recent Mars’ mantle. Major- and trace-element data for Tissint olivine and pyroxene were reported, and these data were used to provide new insights into the dynamics of the Tissint magma chamber, as well as the dynamics and temperature of Martian mantle at the time of Tissint crystallisation. Calculated interior temperatures and the evidence of olivine P-zoning related to convective activity places important constraints on the modern magmatic activity of Mars.

Part of the Building Worlds Seminar Series
building_TRANSP-01
 by the UK Centre of Astrobiology
Screenshot 2020-02-05 at 16.56.57