Comment for CW

Comment for Chemistry World News on a recent article by A. Wolos et al “Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry” published in Science.

It is great to see the use of computers to combine our chemical knowledge, to enable predicting new chemical pathways. The team, previously known for software Chematica, lead by Bartosz Grzybowski and Sara Szymkuć, demonstrated how this can be used to map-out reactions from most simple early Earth ones towards the building blocks of life.

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talk to your Scientist Next Door

As a small community of scientist from the Universities of Edinburgh and Durham, we started project.

Our aim is to share our passion for science with children that are now bound to be homeschooled through the COVID-19 lockdown.

We believe this time can become a life-changing opportunity and help bring up a new generation of fantastic scientists!

During the lockdown, we will hold group video calls with families and discuss topics of interest, share ideas and resources.

We have called this project Scientist Next Door as we think after the lockdown is over, it would be great to meet in person your neighbouring scientists!

You can learn more about scientists participating to this project here. And if you are a scientist and would like to join us, contact Valentina.

And for now, stay home, stay safe, look after yourselves and loved ones and join the forum and the upcoming video calls.




Titan's layered atmosphere on display.

Astrobiology through a Computer

When we think of chemistry, we often imagine a laboratory bench full of test tubes and a scientist in a white coat. But as we accumulate knowledge through such experiments, we start to formulate them into theories and hypothesis. Testing such hypotheses allows us to refine our theories, ultimately gaining predictive power. Additionally, computational chemistry methods provide us with a versatile tool, bringing atomic-level insights to processes beyond conditions attainable in the lab. It comes as no surprise that it is extensively applied for the search of chemical processes of the origin of life.

In this search, we are biased towards “life as we know it” – made of polymeric self-organising sequences in an aqueous media confined by a flexible lipid membrane. Life forms of this kind would only exist in Earth-like conditions, giving rise to the interest in planets in the “habitable zone” (planets that can have liquid water on their surface).

Polar clouds, made of methane, on Titan (left) compared with polar clouds on Earth (right), which are made of water or water ice.
Polar clouds, made of methane, on Titan (left) compared with polar clouds on Earth (right), which are made of water or water ice. Wikimedia Commons

Titan, the moon of Saturn, with a cryogenic surface (-180 °C) cannot have liquid surface water. Instead, it has hydrocarbon (that exists as natural gas on our planet) seas, and it snows benzene. It also has a dense atmosphere with a wide diversity of organic molecules produced through photochemical reactions. It opens a playground for the ideas of exotic life.

Indeed, when recreating the chemistry of the Titan’s atmosphere, Horst et al. were able to observe the formation of nucleotides and amino acids, essential building blocks of polymers of our life. The significance here was that these core reactions, first discovered in Miller-Urey experiment, and believed to require water, could go on without it.

Furthermore, Stevenson et al. then postulated the possibility of formation of pseudo-membranes in liquid-water-free environments, by such aiming to expand the search for life beyond “habitable zone”. As an example, they studied self-assembly of molecules found on Titan. Within those, acrylonitrile was predicted to form a flexible inverse-membrane, named azotosome.

However, recent theoretical work by Sandström and Rahm curbs our excitement for finding traces of exotic life. Through molecular modelling, they studied other plausible structures that acrylonitrile could adopt in Titan’s frigid environment, where entropy plays a very small role. They demonstrated that its crystal is significantly energetically more stable than its membrane-like azotosome.

These two works demonstrate how, through computational chemistry, we can test and challenge new ideas in conditions unattainable on Earth. As a result, we are growing and evolving our understanding of the physicochemical processes and engaging in extensive discussions on the processes of life.

Computational methods are advancing, giving us the capacity to analyse the chemical space with increasing efficiency and to drive our imagination further, germinating new ideas.

by V Erastova


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PhD “Molecular Modeling for Design of Biochar Materials”


The project brings molecular modeling into biochar research, providing atomistic details to the key properties of biochar, and through this enabling the informed design and optimization of biochar for desirable functionality.

Full project description here

Supervisors Valentina Erastova and Ondrej Masek, UK Biochar Research Centre

Start: September 2020

Eligibility: Fully funded for UK and EU (with ILR) citizens

Deadline: 9th January 2020

Application process information here